Same for me, even the creation of a music database fails.
19:47:22 M: 44163072 NOTICE: Attempting to update the database MyPrograms6.db from version 0.00 to 0.80
19:47:22 M: 44167168 ERROR: SQLite: Some kind of disk I/O error occurred
Query: CREATE TABLE version (idVersion float)
19:47:22 M: 44167168 ERROR: Error attempting to update the database version!
19:47:22 M: 44167168 ERROR: Can't update the database MyPrograms6.db from version 0.00 to 0.80
19:47:22 M: 43966464 ERROR: SQLite: SQL error or missing database
Query: select xbedescription,iTimesPlayed,lastAccessed,titleId from files where strFileName like 'F:\Games\2006 FIFA World Cup\default.xbe'
19:47:22 M: 43966464 ERROR: CProgramDatabase::GetProgramInfo(F:\Games\2006 FIFA World Cup\default.xbe) failed
19:47:22 M: 43966464 ERROR: SQLite: SQL error or missing database
Query: insert into files (idFile, strFileName, titleId, xbedescription, iTimesPlayed, lastAccessed, iRegion) values(NULL, 'F:\Games\2006 FIFA World Cup\default.xbe', 1161887900, '2006 FIFA World Cup', 0, 127951264427700000, -1)
19:47:22 M: 43966464 ERROR: CProgramDatabase::AddProgramInfo(F:\Games\2006 FIFA World Cup\default.xbe) failed
19:47:22 M: 43966464 ERROR: SQLite: SQL error or missing database
Query: select * from trainers where idTitle=1161887900
19:47:22 M: 43966464 ERROR: error checking for title's trainers (select * from trainers where idTitle=1161887900)
19:47:22 M: 43966464 ERROR: SQLite: SQL error or missing database