I'm pretty sure you guys know about the first one, set the video mode to PAL & the game actually plays slower than usual(still playable btw), this is for all those people who jam screw, shit is pretty funny.
As for mame, I've done this to TMNT & X-men. Map all four players' buttons to the same controller & jack the difficulty to the highest setting. I think TMNT had hella slowdown on the last stage cos there were so many damn enemies on the screen!
Try those two out & if you know any other emu tricks let us know.