I was having the same troubles as everyone else, IGR=On, TSR=Normal - nothing happens. Then I read from xboxistheshiznit that you must launch the game from evox (I was running the game from boot up), but when I tried to do that, Ninja Gaiden would not load. After trying everything else I could think of, I tried switching the region to "Auto" and then everything worked perfectly. I thought this was strange because before I had it set to NTSC and I know for sure that it is the NTSC version of NG, but this would not work. Just to make sure, I set it back to NTSC and sure enough the game would not load again. Anyway, thought I would throw this into the mix of things to try since I didn't see anyone else get it to work this way.