I know it doesn't matter if it has USB or not for mice, but If they do release a mouse I see it being wired instead of wireless, since wireless takes batteries and are heavy which no one wants, right now wireless mice suck, unless you blow $80 for a MX900 or something. Of course it would be a M$ released mouse, but it would still help if the 360 was compatable. Alot of games would be easier and more enojayble, such as music mixing games or alot of puzzle games. There really isn't a reason not to, even if there is no web surfing. It's rather easy to get a mouse running on a system, as it was said for the PS2, and seeing as the xbox360 is more based on PC type architecture I couldn't imagine it would be very difficult.