Just got this remote... It's good. Responsiveness is good, the lag is not really noticeable on mine. Definitely shorter than the lag described in earlier posts. I didnt even have to change interkey or interdevice delay.
The Activity macros work really well and fast, I thought I would hate the macros but they work awesome... Its really convenient since I was juggling a receiver remote, digital cable box, tv remote and xbox360 remote.
If you screw up the Activity macro by not pointing the remote at the devices you just press Help and it has a quick wizard to turn things on or change inputs.
And if you really hate macros just push the Devices button and the remote dedicates all its functions for your tv, receiver, or xbox360. It also has an IR port on the bottom for learning commands.
Build quality is also great. Rubberized underside, buttons have different textures and shapes, and none of them have the mushy vague feeling.