Nevermind cheema201...turns out there were some other default settings I had to change to fix the audio as well. I found better settings for Metal Gear Solid (audio fix and intro fix)...gameplay is great:
Metal Gear Solid (iso):BIOS Mode: BIOS File
Core Version: 1.5
GPU Plugin Version: 1.16
SPU Plugin Version: 1.9
Set Graphic Fixes: Turn everything "Off"; except for Framelimit......leave Framelimit "ON", Bit Depth=16
Set CPU Fixes: Everything should be "Off"
Set SPU Fixes:
-XA Sound= "On"
-XA Speed Fix= "On"..........this fixes the intro
-Reverb= "Simple"
-Interpolation = Gaussian/Good
-Wait CPU Action= "On"
-IRQ in Decoded Sound Buf= "Off"
-Sound Timer Method= "Original"........helps out the Wait CPU Action as "Threaded" makes audio too slow
Throttle Method= "Original"
OOPs.......turns out I left a setting out. Just make sure that "Use old frame skipping" is turned ON under "Set graphics fixes" if using v21
Tested out my settings again today. Sorry about that
Runs very well.