If you set all paths to D:\ then it won't work because the emu needs to write data to most of those folders. So you need to set up your path.ini like this:
E:\SAVES\ZSNEXBOX\artwork\Shots 1\
E:\SAVES\ZSNEXBOX\artwork\Shots 2\
E:\SAVES\ZSNEXBOX\artwork\Shots 3\
E:\SAVES\ZSNEXBOX\artwork\Shots 4\
E:\SAVES\ZSNEXBOX\artwork\Shots 5\
E:\SAVES\ZSNEXBOX\artwork\Shots 6\
E:\SAVES\ZSNEXBOX\artwork\Shots 7\
E:\SAVES\ZSNEXBOX\artwork\Shots 8\
E:\SAVES\ZSNEXBOX\sram\
E:\SAVES\ZSNEXBOX\save\
E:\SAVES\ZSNEXBOX\ini\
E:\SAVES\ZSNEXBOX\rumble\
E:\SAVES\ZSNEXBOX\cheats\
E:\SAVES\ZSNEXBOX\garbage\
D:\roms\
The only problem is that the E:\ folders must exist on the HDD before you launch your Zsnexbox disc or it will just crash. Zsnexbox does not automatically create the folders it needs like other emus do.
EDIT: Looks like nes6502 beat me to it.
