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[ldotsfan]

You have to provide more details on what exactly you were trying to do, for example:
1. Are you doing a hdd upgrade or hotswapping to softmod?
2. Are you following any tutorial? Which one? How did you prepare/format the usb drive?
3. Disabling dvd drive in Windows Device manager doesn't do anything useful since xboxhdm is Linux.
4. Are you aware for the most part, an usb ide adapter won't be able to lock a new hdd unless it uses specific chipset?

[ldotsfan]

You meant scullc's qemu guide included int the xboxhdm2.2 download?

How exactly are you doing the hotswapping?