Assuming the HD is locked and you don't got the EEPROM your fucked, you'll need a new HD. If you have the EEPROM, you can unlock it.
A possible modchipless fix (A bit dangerous!) would be to boot a good Xbox, load up an EEPROM flasher utility, swap the EEPROM chip to the bad one, then flash it. Probably your best bet for such a hack would be to "stack" EEPROM chips (which involves switching between a VCC line, allowing you to boot one chip and flash another).
You can boot a modchip with an embedded EEPROM or one with debug capability so you can reflash the EEPROM chip. You can either flash a new EEPROM and lock an unlocked HD for the Xbox, or you can use a backup EEPROM (Which in case you won't need a new HD or anything).
You can't just lock a hard drive for a blank EEPROM. A blank EEPROM would have a corrupted video output, and wouldn't play any games because the region would be incorrect.
One good reason to backup your EEPROM, use shadow features, and not fuck with tools like ConfigMagic!