Xbox 1.6, latest version of Evox, X3.
I backed it up using Px HDD Loader or whatever it's called. I go to play the game from Evox, nothing, boots back. I went to disable TSR, IGR, nothing. Updated bios, set settings to default, turned off IGR in X3 Config Live, and STILL nothing!
Decided to try to run it through XBMC, and voila, it works. I had to disable IGR for it to work in XBMC. However, I quit after playing a while, went to play again later, and it booted back to Evox. WTF?
I read on another forum try using different dashboards. So I went to the xbins ftp site, got Avalaunch, extracted it to f:\apps, and GTA works fine. TSR and IGR are enabled, nothing special needs to be set. It just works fine using Avalaunch.
I also read that Unleash X works just fine too.
My suggestion: Try using a couple different dashboards. I dont understand how some people run the game fine by disabling one setting, but the same solution wont work for someone else. I guess it might have something to do with your DVD or what xbox version you have, or a combination of settings. Who knows, I'm no expert. But I do know put on a couple dashboards, leave settings at default, and see which one works for you. I dont mind having Avalaunch sitting there if it's just used for GTA.
Good luck people! It's a great game..