My Mass Effect 2 isn't swapping discs with this, I'm on Dash 12611 with Dashlaunch 2.21.
; this ini has the same rules as launch.ini and must be placed on the root of a device
; paths are determined the same way (Usb/Hdd/etc) see dash launch sample ini for more info
; title ID is used for ini category (can be found in fsd, with xextool, the folder name built by iso2god/nxe install)
; use only numbers and small letters here
; only disks listed in the correct titleid category will be parsed from this ini
[454108df]
; dead space 2
; paths for GOD games must point at the root CON descriptor, and NOT end in a \
disk1 = Hdd:\Content\0000000000000000\454108DF\00007000\831BBD71B701B42512FF
disk2 = Hdd:\Content\0000000000000000\454108DF\00007000\B8605B3BAFB748ACD08A
[5454086c]
; LA Noire
disk1 = Hdd:\Content\0000000000000000\5454086C\00007000\D29C417A095AAB673BF5
disk2 = Hdd:\Content\0000000000000000\5454086C\00007000\31166B60CF4D89293E1F
disk3 = Hdd:\Content\0000000000000000\5454086C\00007000\0EC6A58DDE77D05848D9
[454108ce]
; Mass Effect 2
disk1 = Hdd:\Content\0000000000000000\454108CE\00007000\2AB71BD89DC58E8FB82F
disk2 = Hdd:\Content\0000000000000000\454108CE\00007000\651DFCA81463C5F0E6B4
I'm getting around to playing the other games to test them, but with ME2 I have a savefile right before you need to swap back to disc 1, and it's not doing anything.