I always install and FTP via ISO2GoD and I run PAL games all the time on my NTSC/U JTAG'd boxes. Funny things happen very rarely but luckily nothing to do with PAL vs NTSC (which might cause timing issues) because I use Component or HDMI (normally you would just get a black screen if something attempted PAL on an NTSC TV in the US; find me one that supports PAL!).
I suppose ISO2GoD does do the region patching as it creates the package, which is awesome. No, I cannot run iXtreme-compatible PAL games via the dashboard either. One thing I have not tried is burning the game files to disc like normal unpatched. I suppose this is where I would run into the 360 stating that the binary is not region-free.
When I say strange things (PAL on NTSC), one good example is Dancing Stage Universe (PAL) vs Dance Dance Revolution Universe (NTSC). If I run DS Universe from XM360, DS Universe does run a detection of my console's region then all of a sudden the game is in NTSC mode and the logos, and even the song selection changes (due to licensing). XM360 does some sort of auto-patching it seems. I know it's running PAL if it says 'This game is licensed for Europe only' in one of the starting graphics. If run from the dashboard, works fine whether it's off a disc or my HDD. Again, the more likely reason I do not see black is due to usage of non-AV cables. On an 'old TV', I might see black in attempting to run DS Universe. Not sure yet, haven't tried (and I don't want/need to).
Just in case you are wondering also, timing is NOT affected at all in DS Universe when played on NTSC console, which is awesome in comparison to the PS2 days of running PAL games (with auto-patch via modchip or manually applied patch via VFIX).
All the Japanese games I've tried have worked (MOST Japanese titles are NOT region-free), including Strike Witches as raw files (don't know if the XEX was patched), not a GoD package.
QUOTE(danthaman673 @ Sep 26 2010, 09:51 AM)

One should never have to go to the length of patching a KV (Unless all ur titles are under ONE other region AND you have a Xenon OR don't mind trying to run older games on XBR (That don't demand update etc ..)
100% agreed. Not risking my NANDs for this.