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[smartygre1]

It doesn't work the same way as in the old xbox.  

I am not at home but here goes.

At the line of scrimmage, pull the left trigger to show the routes.

While viewing the routes, push the button the player whose route you want to change, he will then be highlighted in red.

Let go of the left trigger.  

Push the right button (blue maybe) then the top button (Yellow?) then the d-pad in the direction of the new route (outs, ins, etc)

your QB will audibleize and you got it.

it takes some getting used to.

[Ces2k3]

or u can just go to the reciever and press y and  u can do the hot route like that.

[XBANDGUY]

Highlight the player you want to do a hot route with. Then press Y and d-pad in the direction of the hot route you wan to use.

[JMan8108]

Highlight the reciever then press y and i use the sticks to set my hot routes