yeah I know, its from 1up, but right now I'll take any news...
We've got a list of developers who are attending MS's X05 event in Amsterdam, from which we've deduced what games they will be announcing or talking about, sometimes based on industry rumors. We'll know for sure in a few hours or so anyway, so let the imagination run wild.
Real Time Worlds: Crackdown, a GTA-like action shooter set in the near future.
Bioware:

Rumors surfaced a little while ago that our friends in Canada have been working on another original IP. The fact that they are in Amsterdam suggests they will be announcing something big for 360.
Epic: Gears of War, but we already knew that.
Silicon Knights: Too Human
EA: the rumor is their unannounced 360 game is based on a famous comic IP. Which one? One that hasn't been done yet - can you fill in the blanks?
Ubisoft: rumored to show something big that isn't Ghost Recon--our guess? Perhaps something new starring Sam Fischer?
In addition, we know for sure that we'll be seeing the following: PDZ, Kameo, PGR3.
If theres anything regarding Splinter 4...I will fuggin die. Gears AND Splinter 4?! at the same show!?