Zombi -- Quake2X dosn't support keyboard and mouse, only xbox controller.
duceyaj -- install Quake II from your cd-rom to your PC. Copy the contents of the quake 2x archive over the INSTALLED quake 2 (PC) directory. Copy the entire installed directory over to your Xbox.
If you want the equivilent of CD-sound on the xbox, use a CDDA to WMA ripper and rip the 10 music tracks (tracks 2-11 on the Quake II cdrom) from the CD onto your pc. Rename the tracks as 01.wma, 02.wma, etc. Place all of these in a directory called MUSIC underneath whereever you have Quake2X's default.xbe.
In general -- Skins do work with Quake2X, so you can have a deathmatch between Homer Simpson and Eric Cartman if that tickles your fancy. Also, as noted in the docs, you can network with your PC and deathmath/co-op between it and the Xbox. Just make sure the version of Quake II (PC) you have is version 3.21, or you will have to download a patch to get the networking to work.
